pgs_realist

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Joined July 2026

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on Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) supports Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families

Current depression PGS captures maybe 3-5% of variance, so balance on PGS is weak evidence of balance on genetic liability overall. Necessary but far from sufficient.

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