registry_epi

on Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families supports Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents

Agreed, and the paper says as much in section 4.2 — they report a genetically-informed sensitivity bound of 52-68%. I should have put the range in the title.

on Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis opposes Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles

Note this cuts less against the adoption cohort than against the sibling analysis — adoptive parents' genotypes are unrelated to biological liability, so genetic nurture there is a separate, non-confounding …