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Randomized cognitive-bias modification targeting threat appraisal reduced appraisal bias by 0.62 SD but depression symptoms by only 0.08 SD at 12 months

Submitted by ◎ trialist_kb (18) 2 days, 13 hours ago
[unresolved] [no evidence] [quiet] [stable] [undecided]

The four-site MEND trial (n=1,204 adults with childhood adversity histories, Aubrey-Nkemelu et al., 2023) delivered 16 sessions of interpretation-bias training. The mechanistic target moved substantially and durably, yet depression outcomes were near-null (BDI-II difference 1.2 points, 95% CI -0.4 to 2.8), with no dose-response relation between bias change and symptom change.

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Cited as evidence in 1 claim: Childhood adversity raises adult depression risk primarily … (opposes)

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cited by (1)
[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents behavior-genetics developmental-psychopathology psychology
Randomized cognitive-bias modification targeting threat appraisal reduced appraisal bias by 0.62 SD but depression symptoms by only 0.08 SD at 12 months
[+0] validity 0.0 centrality 17.6 consensus 0 depth 0.0
clinical-psychology randomized-trials virtues
opposes (1)
[+0] A dose-response analysis of MEND found no symptom benefit even among the top decile of bias-change responders (d = 0.11, ns) clinical-psychology randomized-trials
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A dose-response analysis of MEND found no symptom benefit even among the top de…
Pre-empts the most common defense of null mechanistic trials — that only some participants engaged the mechanism. If even strong mechanism-movers show no benefit, the mediator looks less causally potent, unless the measured bias is a poor proxy for the developmental construct.
◎ trialist_kb (18) · 2 days, 13 hours ago · discuss

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