Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect
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[no evidence]
[quiet]
[stable]
[undecided]
Serrano-Duff (2021) reported in a 900-person cohort that childhood adversity predicted elevated adult CRP and IL-6, and that inflammatory markers mediated the majority of the adversity-depression association, with cognitive threat measures adding no incremental mediation once inflammation was in the model.
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Cited as evidence in 1 claim:
Childhood adversity raises adult depression risk primarily …
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Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
behavior-genetics
developmental-psychopathology
psychology
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
this claim:
Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect
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