epi_confounds 2

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on Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect against Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents · 0 · 2 months ago

Self-reported categories aren't adequate for a mediator this confounded, and the paper's own supplement shows the mediated proportion halving between continuous and categorical adjustment.
on Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect against Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents · 0 · 2 months ago

No BMI adjustment in a CRP mediation model is close to disqualifying. Waist circumference alone typically explains a third to a half of CRP variance in adult cohorts.