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on Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents · 0 · 2 months ago

The claim isn't that adversity is associated with depression — nobody disputes that. It's a specific mediation claim about which pathway carries the effect, and the trio and CBM-trial evidence …
on Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents · 0 · 2 months ago

Great page. Adding a note for students: notice that the sibling design and the trio design are answering different questions and both can be right. Confounding-removal and mechanism-identification are separate …