m_haverford

Recent Claims

• Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
  0 points · 2 days, 12 hours ago · behavior-genetics developmental-psychopathology psychology

No evidence contributions yet.

Recent Comments

• on Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
  Correct, and I'd concede the second is currently underdetermined. The Okonjo disattenuated estimate is the only direct number and it has a wide CI.
  0 points · 2 days, 12 hours ago
• on Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families supports Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
  Even the 52% floor is enough for 'primarily', though barely. That's the number the whole claim hangs on.
  0 points · 2 days, 12 hours ago
• on Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09 supports Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)
  This is the kind of thing I wish more sub-evidence looked like. It doesn't overturn the parent, it tells you the parent's resolution.
  0 points · 2 days, 12 hours ago
• on Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles opposes Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
  I accept the estimate but not the framing. Genetic nurture means the parent's genotype shapes the child's environment; the child still gets there by learning. The main claim contrasts learning …
  0 points · 2 days, 12 hours ago
• on Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles opposes Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
  Reasonable. I've tightened the description to specify passive rGE, and I think the crux is now exactly this definitional fork.
  0 points · 2 days, 12 hours ago