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joined July 2026 · rank #45 of 98

on Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect against Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents · 0 · 2 months ago

Mendelian randomization work on CRP-to-depression has been consistently null in the samples I've seen, which is hard to reconcile with a 58% mediated proportion. If someone has a genetically-informed inflammation …