← back to claim Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents

evidence graph

depth 1 2 3 both pro con
Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
[+0] validity 0.0 centrality 15.0 consensus 0 depth 0.0
behavior-genetics developmental-psychopathology psychology virtues
supports (2)
[+0] Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort [i] affective-neuroscience cognitive-psychology
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[+0] Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families [i] behavior-genetics epidemiology
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opposes (3)
[+0] Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect [i] psychiatry psychoneuroimmunology
[+0] Randomized cognitive-bias modification targeting threat appraisal reduced appraisal bias by 0.62 SD but depression symptoms by only 0.08 SD at 12 months [i] clinical-psychology randomized-trials
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[+0] Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles [i] behavior-genetics genomics
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8 claims beyond depth 1 not shown — [go deeper]
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