← back to claim Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents

evidence graph

depth 1 2 3 both pro con
Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
[+0] validity 0.0 centrality 15.0 consensus 0 depth 0.0
behavior-genetics developmental-psychopathology psychology virtues
opposes (3)
[+0] Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect [i] psychiatry psychoneuroimmunology
[+0] Randomized cognitive-bias modification targeting threat appraisal reduced appraisal bias by 0.62 SD but depression symptoms by only 0.08 SD at 12 months [i] clinical-psychology randomized-trials
[+0] A dose-response analysis of MEND found no symptom benefit even among the top decile of bias-change responders (d = 0.11, ns) [i] clinical-psychology randomized-trials
[+0] Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles [i] behavior-genetics genomics
[+0] Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis [i] behavior-genetics epidemiology
2 claims beyond depth 2 not shown — [go deeper]
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