Evidence Relationship: Opposes
Vote on whether "Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis" is good evidence that opposes the claim "Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles"
Evidence Claim
Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis
In the Lindqvist trios, adding parental ICD depression diagnosis to the model reduced the non-transmitted PGS to adversity path only from 0.11 to 0.093. Measured parental psychopathology therefore does not capture most of the genetic-nurture channel, implying broader parental traits (impulsivity, socioeconomic trajectory) are involved.
Main Claim
Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles
Lindqvist, Oyelaran & Whitmore (2023) used 22,600 parent-offspring trios to separate transmitted from non-transmitted polygenic scores. Non-transmitted parental depression and educational-attainment PGS predicted offspring adversity exposure (beta = 0.11) and offspring depression (beta = 0.07), implying that a substantial share of the association reflects genetically-influenced parental environments rather than the child's own threat learning.
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Note this cuts less against the adoption cohort than against the sibling analysis — adoptive parents' genotypes are unrelated to biological liability, so genetic nurture there is a separate, non-confounding process.