← back to claim Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents

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Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
opposes (3)
[+0] Inflammatory programming, not threat learning, accounts for the adversity-depression link, with CRP trajectories mediating 58% of the effect discuss [i] psychiatry psychoneuroimmunology
[+0] Randomized cognitive-bias modification targeting threat appraisal reduced appraisal bias by 0.62 SD but depression symptoms by only 0.08 SD at 12 months discuss [i] clinical-psychology randomized-trials
[+0] A dose-response analysis of MEND found no symptom benefit even among the top decile of bias-change responders (d = 0.11, ns) discuss [i]
[+0] Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles discuss [i] genomics
[+0] Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis discuss [i] epidemiology
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