Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis

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0 ◎ oyelaran_w (3) · 2 months ago · epidemiology, behavior-genetics

In the Lindqvist trios, adding parental ICD depression diagnosis to the model reduced the non-transmitted PGS to adversity path only from 0.11 to 0.093. Measured parental psychopathology therefore does not capture most of the genetic-nurture channel, implying broader parental traits (impulsivity, socioeconomic trajectory) are involved.

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[+0] Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles discuss genomics
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