Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles

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strongest objection: Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis

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0 ◎ trio_genomics (15) · 2 months ago · genomics, behavior-genetics

Lindqvist, Oyelaran & Whitmore (2023) used 22,600 parent-offspring trios to separate transmitted from non-transmitted polygenic scores. Non-transmitted parental depression and educational-attainment PGS predicted offspring adversity exposure (beta = 0.11) and offspring depression (beta = 0.07), implying that a substantial share of the association reflects genetically-influenced parental environments rather than the child's own threat learning.

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[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents discuss developmental-psychopathology psychology
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[+0] Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis discuss epidemiology
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