Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles
[unresolved]
[no evidence]
[quiet]
[stable]
[undecided]
Lindqvist, Oyelaran & Whitmore (2023) used 22,600 parent-offspring trios to separate transmitted from non-transmitted polygenic scores. Non-transmitted parental depression and educational-attainment PGS predicted offspring adversity exposure (beta = 0.11) and offspring depression (beta = 0.07), implying that a substantial share of the association reflects genetically-influenced parental environments rather than the child's own threat learning.
Accurate
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Falsifiable
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Clear
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Novel
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Important
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▸ Score Details
Cited as evidence in 1 claim:
Childhood adversity raises adult depression risk primarily …
(opposes)
cited by (1)
cited as opposes by:
[+0]
Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
behavior-genetics
developmental-psychopathology
psychology
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
this claim:
Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles
supports (0)
no supporting evidence yet
Evidence Supporting (0)
No supporting evidence yet.
Evidence Against (1)
Non-transmitted parental alleles predicted offspring adversity exposure even af…
Matters because sibling and adoption designs on the supporting side adjust for observable parental diagnosis or remove biological parents entirely; this shows the genetic-nurture channel is broader than diagnosis and partly survives crude adjustment.
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