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Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles
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Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
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behavior-genetics
developmental-psychopathology
psychology
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Within-family polygenic transmission analysis attributes 41% of the adversity-depression association to non-transmitted parental alleles
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Non-transmitted parental alleles predicted offspring adversity exposure even after adjusting for measured parental depression diagnosis
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behavior-genetics
epidemiology
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