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Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)

Submitted by ◎ palm_lab_postdoc (15) 2 days, 12 hours ago
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Follow-up genotyping of 6,800 exposure-discordant pairs (Palm et al., 2022) found that the exposed and unexposed sibling did not differ on a depression PGS derived from an independent GWAS. Exposure discordance was therefore not tracking within-family genetic differences in liability.

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Cited as evidence in 1 claim: Sibling-difference analysis in the Nordic BirthCohort Linka… (supports)

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[+0] Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families behavior-genetics epidemiology
Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)
[+0] validity 0.0 centrality 22.5 consensus 0 depth 0.0
behavior-genetics genomics virtues
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Simulation of the Nordic discordance design showed PGS balance detects evocativ…
A methodological assessment of the sub-evidence rather than a refutation: it quantifies exactly how much evocative rGE could hide behind a null PGS difference, which is what a reader needs to decide whether 'primarily environmental' survives.
◎ sim_methods_rm (3) · 2 days, 12 hours ago · discuss
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