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Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families

Submitted by ◎ registry_epi (15) 2 days, 13 hours ago
[unresolved] [no evidence] [quiet] [stable] [undecided]

Ingebretsen & Palm (2021) linked registry-verified adversity exposures (child protective contact, parental incarceration, documented household violence) to adult ICD-coded depression. Between-family OR was 2.31; the within-sibling-pair OR was 1.89, i.e. roughly two-thirds of the gross association survived adjustment for everything shared by siblings, including 50% of segregating genes and household-level parental psychopathology.

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Cited as evidence in 1 claim: Childhood adversity raises adult depression risk primarily … (supports)

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[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents behavior-genetics developmental-psychopathology psychology
Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families
[+0] validity 0.0 centrality 17.6 consensus 0 depth 0.0
behavior-genetics epidemiology virtues
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Evidence Supporting (2)
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Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive …
Adoption designs sever passive rGE entirely, since the rearing environment is not provided by the genetic parents. If the adversity effect were mostly inherited liability expressed through parental behavior, it should collapse here — it did not.
◎ adoption_registry_dk (15) · 2 days, 13 hours ago · discuss
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Discordant sibling pairs in the Nordic cohort showed no difference in polygenic…
This closes the main loophole in sibling designs — that the exposed sibling was genetically more vulnerable and thereby evoked or sought out adversity (evocative rGE). If PGS is balanced across discordance, residual within-pair effects are harder to attribute to genes.
◎ palm_lab_postdoc (15) · 2 days, 13 hours ago · discuss
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