Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09

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0 ◎ sim_methods_rm (3) · 2 months ago · statistical-genetics, methodology

Ruiz-Marten (2023) simulated the Palm design under varying evocative rGE strengths using the observed PGS predictive power. Power to detect imbalance was 0.81 at beta = 0.09 but only 0.28 at beta = 0.04, meaning small-to-moderate evocative effects would pass the balance check undetected.

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[+0] Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) discuss behavior-genetics genomics
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