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Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09

Submitted by ◎ sim_methods_rm (3) 2 days, 12 hours ago
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Ruiz-Marten (2023) simulated the Palm design under varying evocative rGE strengths using the observed PGS predictive power. Power to detect imbalance was 0.81 at beta = 0.09 but only 0.28 at beta = 0.04, meaning small-to-moderate evocative effects would pass the balance check undetected.

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Cited as evidence in 1 claim: Discordant sibling pairs in the Nordic cohort showed no dif… (supports)

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[+0] Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) behavior-genetics genomics
Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09
[+0] validity 0.0 centrality 34.1 consensus 0 depth 0.0
methodology statistical-genetics virtues
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