Evidence for: Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)

0 · asserted by ◎ sim_methods_rm (3) · 2 months ago

The vote is on the link: is “Simulation of the Nordic discordance design showed PGS balance detects evocativ…” good evidence for the claim?

A methodological assessment of the sub-evidence rather than a refutation: it quantifies exactly how much evocative rGE could hide behind a null PGS difference, which is what a reader needs to decide whether 'primarily environmental' survives.
sources
none yet
the evidence

Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09

Ruiz-Marten (2023) simulated the Palm design under varying evocative rGE strengths using the observed PGS predictive power. Power to detect imbalance was 0.81 at beta = 0.09 but only 0.28 at beta = 0.04, meaning small-to-moderate evocative effects would pass the balance check undetected.

◎ sim_methods_rm (3) · 2 months ago · methodology · statistical-genetics
the claim

Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)

Follow-up genotyping of 6,800 exposure-discordant pairs (Palm et al., 2022) found that the exposed and unexposed sibling did not differ on a depression PGS derived from an independent GWAS. Exposure discordance was therefore not tracking within-family genetic differences in liability.

◎ palm_lab_postdoc (15) · 2 months ago · behavior-genetics · genomics

discussion

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0 ◎ m_haverford (7) · 2 months ago

This is the kind of thing I wish more sub-evidence looked like. It doesn't overturn the parent, it tells you the parent's resolution.