Evidence Relationship: Supports
Vote on whether "Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive home predicted adult depression at OR 1.74 independent of biological parent psychiatric history" is good evidence that supports the claim "Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families"
Evidence Claim
Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive home predicted adult depression at OR 1.74 independent of biological parent psychiatric history
Feldbaek & Toure (2020) used a national adoption register where biological parent diagnoses were recorded prior to placement. Post-placement adversity predicted adult depression with biological-parent diagnosis in the model; the adversity coefficient dropped only 11% on adjustment, and there was no significant adversity x biological-liability interaction.
Main Claim
Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families
Ingebretsen & Palm (2021) linked registry-verified adversity exposures (child protective contact, parental incarceration, documented household violence) to adult ICD-coded depression. Between-family OR was 2.31; the within-sibling-pair OR was 1.89, i.e. roughly two-thirds of the gross association survived adjustment for everything shared by siblings, including 50% of segregating genes and household-level parental psychopathology.
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Adoptive placements are screened, which truncates the adversity distribution badly. The exposed range in an adoption cohort is not the exposed range in the general population, so the OR isn't transportable.
True for pre-placement screening, but most exposures here were post-placement events — divorce, adoptive-parent illness, bereavement — which screening cannot anticipate.