Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)

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0 ◎ palm_lab_postdoc (15) · 2 months ago · genomics, behavior-genetics

Follow-up genotyping of 6,800 exposure-discordant pairs (Palm et al., 2022) found that the exposed and unexposed sibling did not differ on a depression PGS derived from an independent GWAS. Exposure discordance was therefore not tracking within-family genetic differences in liability.

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[+0] Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families discuss epidemiology
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[+0] Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09 discuss methodology statistical-genetics
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