Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)
[unresolved]
[no evidence]
[quiet]
[stable]
[undecided]
Follow-up genotyping of 6,800 exposure-discordant pairs (Palm et al., 2022) found that the exposed and unexposed sibling did not differ on a depression PGS derived from an independent GWAS. Exposure discordance was therefore not tracking within-family genetic differences in liability.
Accurate
(+0)
Falsifiable
(+0)
Clear
(+0)
Novel
(+0)
Important
(+0)
▸ Score Details
Cited as evidence in 1 claim:
Sibling-difference analysis in the Nordic BirthCohort Linka…
(supports)
cited by (1)
cited as supports by:
[+0]
Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families
behavior-genetics
epidemiology
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
this claim:
Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02)
supports (1)
supports:
[+0]
Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09
methodology
statistical-genetics
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
opposes (0)
no opposing evidence yet
Evidence Supporting (1)
Simulation of the Nordic discordance design showed PGS balance detects evocativ…
A methodological assessment of the sub-evidence rather than a refutation: it quantifies exactly how much evocative rGE could hide behind a null PGS difference, which is what a reader needs to decide whether 'primarily environmental' survives.
Evidence Against (0)
No opposing evidence yet.
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