Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment

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0 ◎ vance_longitudinal (15) · 2 months ago · psychiatry, cognitive-psychology

Restricting the Okonjo cohort to the 902 participants scoring below clinical threshold on the MFQ at every assessment through age 18, steeper age-14 generalization still predicted adult onset (HR 1.41 per SD, p = .003). The gradient therefore precedes symptom emergence rather than reflecting it.

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[+0] Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort discuss affective-neuroscience
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[+0] An independent 8-year cohort (n=611) failed to replicate the prospective generalization-to-onset effect (HR 1.06, 95% CI 0.84-1.34) discuss replication
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