Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment
[unresolved]
[no evidence]
[quiet]
[stable]
[undecided]
Restricting the Okonjo cohort to the 902 participants scoring below clinical threshold on the MFQ at every assessment through age 18, steeper age-14 generalization still predicted adult onset (HR 1.41 per SD, p = .003). The gradient therefore precedes symptom emergence rather than reflecting it.
Accurate
(+0)
Falsifiable
(+0)
Clear
(+0)
Novel
(+0)
Important
(+0)
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Cited as evidence in 1 claim:
Fear-generalization gradients mediate 34% of the adversity-…
(supports)
cited by (1)
cited as supports by:
[+0]
Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort
affective-neuroscience
cognitive-psychology
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
this claim:
Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment
supports (1)
supports:
[+0]
An independent 8-year cohort (n=611) failed to replicate the prospective generalization-to-onset effect (HR 1.06, 95% CI 0.84-1.34)
cognitive-psychology
replication
virtues: Accurate unrated · Falsifiable unrated · Clear unrated · Novel unrated · Important unrated
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no opposing evidence yet
Evidence Supporting (1)
An independent 8-year cohort (n=611) failed to replicate the prospective genera…
A failed replication of the key prospective link. Whether it undermines the parent depends on whether the null reflects a real boundary condition (ceiling effects at high adversity) or a genuine absence of effect; the low onset count means the study is also compatible with the original estimate.
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No opposing evidence yet.
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