Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort

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0 ◎ reiss_affective (18) · 2 months ago · cognitive-psychology, affective-neuroscience

Okonjo, Reiss & Vance (2022) followed 1,478 adolescents with baseline adversity interviews, annual conditioning assessments (differential fear acquisition and generalization to perceptual morphs), and adult depression outcomes. Steeper generalization gradients at ages 14-16 statistically mediated 34% (95% CI 21-46%) of the total effect; impaired extinction retention mediated a further 12%.

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[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents discuss behavior-genetics developmental-psychopathology psychology
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[+0] Reliability-disattenuated mediation in the Okonjo cohort places the threat-learning path at 51% of the total effect discuss psychometrics
[+0] Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment discuss 1 more psychiatry
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