← back to claim Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort

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depth 1 2 3 both pro con
cited by (1)
[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents [i] behavior-genetics developmental-psychopathology psychology
Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort
[+0] validity 0.0 centrality 17.6 consensus 0 depth 0.0
affective-neuroscience cognitive-psychology virtues
supports (2)
[+0] Reliability-disattenuated mediation in the Okonjo cohort places the threat-learning path at 51% of the total effect [i] cognitive-psychology psychometrics
[+0] Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment [i] cognitive-psychology psychiatry
[+0] An independent 8-year cohort (n=611) failed to replicate the prospective generalization-to-onset effect (HR 1.06, 95% CI 0.84-1.34) [i] cognitive-psychology replication
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