Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families

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0 ◎ registry_epi (15) · 2 months ago · epidemiology, behavior-genetics

Ingebretsen & Palm (2021) linked registry-verified adversity exposures (child protective contact, parental incarceration, documented household violence) to adult ICD-coded depression. Between-family OR was 2.31; the within-sibling-pair OR was 1.89, i.e. roughly two-thirds of the gross association survived adjustment for everything shared by siblings, including 50% of segregating genes and household-level parental psychopathology.

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[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents discuss developmental-psychopathology psychology
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[+0] Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive home predicted adult depression at OR 1.74 independent of biological parent psychiatric history discuss
[+0] Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) discuss genomics
[+0] Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09 discuss methodology statistical-genetics
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