← back to claim Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families

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[+0] Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents discuss [i] developmental-psychopathology psychology
Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families
supports (2)
[+0] Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive home predicted adult depression at OR 1.74 independent of biological parent psychiatric history discuss [i]
[+0] Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) discuss [i] genomics
[+0] Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09 discuss [i] methodology statistical-genetics
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