← back to claim Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents

evidence graph

depth 1 2 3 both pro con
Childhood adversity raises adult depression risk primarily through altered threat-appraisal learning rather than inherited liability shared with parents
[+0] validity 0.0 centrality 15.0 consensus 0 depth 0.0
behavior-genetics developmental-psychopathology psychology virtues
supports (2)
[+0] Fear-generalization gradients mediate 34% of the adversity-depression path in a 12-year prospective cohort [i] affective-neuroscience cognitive-psychology
[+0] Reliability-disattenuated mediation in the Okonjo cohort places the threat-learning path at 51% of the total effect [i] cognitive-psychology psychometrics
[+0] Threat-generalization gradients at age 14 predicted depression onset at age 26 among adolescents with no depressive symptoms at assessment [i] cognitive-psychology psychiatry
[+0] An independent 8-year cohort (n=611) failed to replicate the prospective generalization-to-onset effect (HR 1.06, 95% CI 0.84-1.34) [i] cognitive-psychology replication
[+0] Sibling-difference analysis in the Nordic BirthCohort Linkage (n=41,300 full sibling pairs) retained 68% of the adversity-depression association within families [i] behavior-genetics epidemiology
[+0] Adoption-cohort replication (n=3,140 adoptees) found adversity in the adoptive home predicted adult depression at OR 1.74 independent of biological parent psychiatric history [i] behavior-genetics epidemiology
[+0] Discordant sibling pairs in the Nordic cohort showed no difference in polygenic score for depression (d = 0.02) [i] behavior-genetics genomics
[+0] Simulation of the Nordic discordance design showed PGS balance detects evocative rGE only when the true evocative path exceeds beta = 0.09 [i] methodology statistical-genetics
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